Neuroinflammation in fibromyalgia and CRPS is multifactorial, not idiopathic

March 3, 2016


Citation: Vasquez A. Neuroinflammation in fibromyalgia and CRPS is multifactorial. Nature Reviews Rheumatology 2016; March 3: doi:10.1038/nrrheum.2016.25.


Basically what I do in this Correspondence is refute the idea that these "chronic pain" and neuroinflammatory / central sensitization conditions are "idiopathic" and are --rather and importantly-- multifactorial. The distinction is of massive importance, because if we view these conditions as multifactorial we can then begin to dismantle these conditions by addressing the components. Based on my previous work starting in 2004 on migraine (textbook: "Integrative Orthopedics") and 2008 on fibromyalgia (CME monograph: "Musculoskeletal Pain", now replaced by Inflammation Mastery, 4th Edition), I show --working within the constraints of less than 500 words-- that these conditions are triggered and perpetuated by 1) dysbiosis, 2) mitochondrial dysfunction, and 3) nutrient deficiencies, especially vitamin D. Logical treatment thereby follows, as already proven safe and effective by respective clinical trials.


My current textbooks (and previous journal articles) that cover this information are:

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