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Essay/Excerpt: Endoplasmic Reticulum Stress (ERS) and Unfolded Protein Response (UPR)

ERS is obviously an adaptive mechanism, which most likely developed for sensing microbes, and which becomes maladaptive when chronically stimulated by overconsumption of carbohydrates and saturated fats; the sequel UPR is notably appropriate for response to microbes, and notably harmful when activated by habitual dietary excess. When ERS-UPR activation is sustained, the result is excess inflammation and immune system hypervigilance (e.g., pathophysiologic priming for disorders of metabolic/allergic/autoimmune inflammation); more intense activation of ERS may result in apoptosis.