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Neuroinflammation and Central Sensitization in Fibromyalgia and Complex Regional Pain Syndrome: Synergy of Glial Inflammation, Mitochondrial Dysfunction, Gut Dysbiosis (Microbiome Imbalance) and Vitamin D Deficiency
Dr Alex Vasquez


Citation and Hyperlink: Vasquez A. Neuroinflammation in fibromyalgia and CRPS is multifactorial. Nat Rev Rheumatol. 2016 Apr;12(4):242

DOI: 10.1038/nrrheum.2016.25

PMID: 26935282

History and Synopsis: Basically what I do in this Correspondence is refute the idea that these "chronic pain" and neuroinflammatory / central sensitization conditions are "idiopathic" and are —rather and importantly— multifactorial. The distinction is of massive importance, because if we view these conditions as multifactorial we can then begin to dismantle these conditions by addressing the components. Based on my previous work starting in 2004 on migraine (textbook: Integrative Orthopedics) and 2008 on fibromyalgia (CME monograph: Musculoskeletal Pain), I show —working within the constraints of fewer than 500 words— that these conditions are triggered and perpetuated by 1) dysbiosis, 2) mitochondrial dysfunction, and 3) nutrient deficiencies, especially vitamin D. Logical treatment thereby follows, as already proven safe and effective by respective clinical trials. My current textbooks that cover this information are Inflammation Mastery, 4th Edition (2016) and the smaller books derrived/excerpted from that larger textbook. Please note the discount available via; the smaller exerpt books are listed below. 

Books and ebooksInflammation Mastery, 4th Edition (2016) is Chapters 1-5 and is the complete work; the section specific to fibromyalgia and migraine is paper-published identically as Pain Revolution (full color) and Brain Inflammation (black and white). All of these books are available in digital ebook formats for phones, iPad, and computer reading and highlighting. 

Additional hyperlinks

  1. Digital ebook nondiscount/retail Inflammation Mastery 4th Edition:

  2. Pain Revolution for Migraine and Fibromyalgia:

  3. Fibromyalgia Solution:

  4. Migraine and Headache Revolution:

  5. Mitochondrial Medicine Arrives to Prime Time in Clinical Care. Altern Ther Health Med 2014

  6. Mitochondrial Dysfunction and the Emerging Mitochondrial Medicine. Integrative Medicine 2013

  7. Translating Microbiome (Microbiota) and Dysbiosis Research into Clinical Practice: The 20-Year Development of a Structured Approach that Gives Actionable Form to Intellectual Concepts. Int J Hum Nutr Funct Med 2015

  8. The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers. Altern Ther Health Med. 2004

Overview (Part 1) of the Functional Inflammology Protocol

Dr Vasquez introduces the "Functional Inflammology Protocol" at the 2013 International Conference on Human Nutrition and Functional Medicine (PDF brochure); all of DrV's presentations from this conference are available:

Dr Vasquez's "functional inflammology protocol", famously recalled by the FINDSEX ® acronym, is reviewed in this presentation for its application to the three general types of inflammatory diseases/responses: 1) metabolic inflammation, including glial activation and emphasizing the component of mitochondrial dysfunction, 2) allergic inflammation, including asthma and eczema, and 3) autoimmune inflammation, including rheumatoid arthritis, psoriasis, and the many other conditions that Dr Vasquez has detailed in his Integrative Rheumatology books starting in 2006. 

 New publication 2016:  Inflammation Mastery 4th Edition


Samples and excerpts:

Click on PDF (larger PDF with photos) to see inside


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