top of page

Magnesium provides biochemical, anti-inflammatory, analgesic, anti-seizure, anti-anxiety, antidepressant and neuroprotective benefits

Research summary and applications from Dr Alex Vasquez, 14 July 2017

Dr Vasquez's summary: “Animal and human studies have now convincingly demonstrated that 

  1. Magnesium deficiency causes inflammation, and

  2. Improved magnesium nutriture and magnesium supplementation provides an anti-inflammatory benefit and protection against inflammatory diseases.”

In addition to these anti-inflammatory benefits, magnesium is necessary for hundreds of biochemical reactions, including ATP production, and regulation of excitatory NMDA-glutamate receptors via which it provides analgesic, anti-seizure, anti-anxiety, antidepressant and neuroprotective benefits.”


Research excerpt: "Mg status in inflammation, insulin resistance, and associated conditions" by Amanda Batista da Rocha Romero, Fabiana da Silva Lima and Célia Colli; Received: 13 September 2016, Accepted: 5 November 2016, Published: 16 March 2017, Nutrire 201742:6 DOI: 10.1186/s41110-017-0031-4

​"The authors observed the reduction in TNF-α and IL-6 reduced expression of IkBα and NFkB activation. They also found in vitro that mononuclear cells exposed to 2.5 mM MgSO4 decreased the production of inflammatory cytokines after stimulation with different TLR ligands, suggesting that Mg possibly has a broad spectrum anti-inflammatory activity. In USA, the Women’s Health Initiative Observational Study evaluated women of different ethnicities, aged 50–79 years, the association between dietary Mg intake and concentration of systemic inflammation biomarkers (CRP, IL-6, TNF-R2) and endothelial dysfunction (sICAM-1 and sVCAM-1) and E-selectin. The authors observed that an increase of 100 mg/d Mg intake was associated with a decrease in concentration of these inflammatory and endothelial biomarkers [51]. Given the above information, dietary Mg inadequacy seems to be associated to the emergence and evolution of diseases of inflammatory etiology such as obesity, insulin resistance, metabolic syndrome, and cardiovascular disease [345253]."


PDF download of full-text article

 Current "master-source" textbook:  

 Inflammation Mastery 4th Edition

Click to enlarge video to full-screen

Samples of Videos

Inflammation Mastery provides more than 30 hours of videos, presentations, and tutorials to enhance the learning process via video, text, and diagrams. (You can click to enlarge these sample videos.) 

Inflammation Mastery 4th Edition


  • print ISBN 0990620484; digital ISBN 9780990620464

  • Retail: US$250 plus shipping and handling

  • Discount via ICHNFM.ORG: US$170 plus shipping and handling

  • Includes and bypasses everything from Naturopathic Rheumatology, Functional Inflammology, and Functional Medicine Rheumatology

  • No major changes to Chapters 1-3 from the previous Inflammation Mastery / Functional Inflammology published in 2014

  • Major changes and additions from recent publications:

Updates to Chapter 4 include

  • Complete re-write of section on Dysbiosis and Infections (published in 2015 as Human Microbiome and Dysbiosis in Clinical Disease)

  • Inclusion of the anti-viral protocol (published in late 2014 as Antiviral Strategies and Immune Nutrition

  • Inclusion of mTOR protocol (published in 2015 in ebook format as Mastering mTOR)

Updates to Chapter 5 include:

  • Inclusion of Hypertension protocol (previously published as Functional Medicine and Integrative Medicine for Hypertension, and as Integrative Chiropractic Management of High Blood pressure. 

  • Inclusion of Diabetes protocol, restructured for the Functional Inflammology Protocol, originally published in Chiropractic and Naturopathic Mastery of Common Clinical Disorders 

  • Complete page-by-page update of Migraine and Fibromyalgia protcols, recently published as a separate monograph:

  • Inclusion of Behçet's Disease, Sarcoidosis, Dermatomyositis and Polymyositis with slight updates from previous editions of Integrative Rheumatology


  1. Chapter 1. Patient Assessments, Laboratory Interpretation, Clinical Concepts, Patient Management, Practice Management and Risk Reduction: This chapter introduces/reviews/updates patient assessments, laboratory interpretation, musculoskeletal emergencies, healthcare paradigms; the common and important conditions hemochromatosis and hypothyroidism are also included in this chapter since these need to be considered on a frequent basis in clinical 1

  2. Chapter 2. Wellness Promotion & Re-Establishing the Foundation for Health: Reviewed here are diet, lifestyle, psychosocial health, and—given the pervasiveness of persistent organic pollutants and their increasingly recognized clinical importance—an introduction to environmental 187

  3. Chapter 3. Basic Concepts and Therapeutics in (Nondrug) Musculoskeletal Care and Integrative Pain Management: Nonpharmacologic management of musculoskeletal problems is preferred over pharmacologic (e.g., NSAID, Coxib, steroid, opioid) management because of the collateral benefits, safety, and cost-effectiveness associated with manual, dietary, botanical, and nutritional treatments. A brief discussion of the current crisis in musculoskeletal medicine is provided for contextualization and emphasis of the importance of expanding clinicians' knowledge of effective nondrug 243

  4. Chapter 4. The Major Modifiable Factors in Sustained Inflammation: Major components of the “Functional Inflammology Protocol” are reviewed here, from concepts and molecular biology to an emphasis on practical clinical 303

   1) Food & Basic 307
   2) Infections: Dysbiosis / 396 / 540
   3) Nutritional 609
   4) Dysmetabolism, Mitochondrial Dysfunction, ERS/UPR, 622
   5) Special Considerations: Sleep, Sociopsychology, Stress, 674
   6) Endocrine 688
   7) Xenobiotic 699

5.  Chapter 5. Clinical 713

   1) 727
   2) Diabetes 819
   3) Migraine & 863
   4) 901
   5) Allergic 984
   6) Rheumatoid 1019
   7) Psoriasis and Psoriatic 1038
   8) Systemic Lupus 1053
   9) Scleroderma & Systemic 1074
   10) Vasculitic 1094
   11) Spondyloarthropathies & Reactive 1108
   12) Sjögren Syndrome/ 1119
   13) Raynaud's Syndrome/Phenomenon/ 1127
   14) Clinical Notes on Additional Conditions: Behçet's Disease, Sarcoidosis, Dermatomyositis and 1131

Index & Appendix -- page1154



Inflammation Mastery 4th Edition provides more than 30 hours of video instruction from live conference presentations, teaching sessions with graduate and post-graduate students, and pre-recorded tutorials.

ICHNFM Courses, Books, Membership, Newsletter

Samples and excerpts: Click on PDF (larger PDF with photos) to see inside. Get all the protocols immediately in your iPad, phone and computer via Amazon's free Kindle software for iPad, phone, and computer. 

Samples and excerpts: Click on PDF (larger PDF with photos) to see inside.

Get all the protocols immediately in your iPad, phone and computer via Amazon's free Kindle software for iPad, phone, and computer. 


bottom of page