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Magnesium provides biochemical, anti-inflammatory, analgesic, anti-seizure, anti-anxiety, antidepressant and neuroprotective benefits

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Research summary and applications from Dr Alex Vasquez, 14 July 2017

ichnfm.org/mg

Dr Vasquez's summary: “Animal and human studies have now convincingly demonstrated that 

  1. Magnesium deficiency causes inflammation, and

  2. Improved magnesium nutriture and magnesium supplementation provides an anti-inflammatory benefit and protection against inflammatory diseases.”

In addition to these anti-inflammatory benefits, magnesium is necessary for hundreds of biochemical reactions, including ATP production, and regulation of excitatory NMDA-glutamate receptors via which it provides analgesic, anti-seizure, anti-anxiety, antidepressant and neuroprotective benefits.”

 

Research excerpt: "Mg status in inflammation, insulin resistance, and associated conditions" by Amanda Batista da Rocha Romero, Fabiana da Silva Lima and Célia Colli; Received: 13 September 2016, Accepted: 5 November 2016, Published: 16 March 2017, Nutrire 201742:6 DOI: 10.1186/s41110-017-0031-4

​"The authors observed the reduction in TNF-α and IL-6 reduced expression of IkBα and NFkB activation. They also found in vitro that mononuclear cells exposed to 2.5 mM MgSO4 decreased the production of inflammatory cytokines after stimulation with different TLR ligands, suggesting that Mg possibly has a broad spectrum anti-inflammatory activity. In USA, the Women’s Health Initiative Observational Study evaluated women of different ethnicities, aged 50–79 years, the association between dietary Mg intake and concentration of systemic inflammation biomarkers (CRP, IL-6, TNF-R2) and endothelial dysfunction (sICAM-1 and sVCAM-1) and E-selectin. The authors observed that an increase of 100 mg/d Mg intake was associated with a decrease in concentration of these inflammatory and endothelial biomarkers [51]. Given the above information, dietary Mg inadequacy seems to be associated to the emergence and evolution of diseases of inflammatory etiology such as obesity, insulin resistance, metabolic syndrome, and cardiovascular disease [34, 52, 53]."

 

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Contents:

  1. Chapter 1. Patient Assessments, Laboratory Interpretation, Clinical Concepts, Patient Management, Practice Management and Risk Reduction: This chapter introduces/reviews/updates patient assessments, laboratory interpretation, musculoskeletal emergencies, healthcare paradigms; the common and important conditions hemochromatosis and hypothyroidism are also included in this chapter since these need to be considered on a frequent basis in clinical practice...page 1

  2. Chapter 2. Wellness Promotion & Re-Establishing the Foundation for Health: Reviewed here are diet, lifestyle, psychosocial health, and—given the pervasiveness of persistent organic pollutants and their increasingly recognized clinical importance—an introduction to environmental medicine...page 187

  3. Chapter 3. Basic Concepts and Therapeutics in (Nondrug) Musculoskeletal Care and Integrative Pain Management: Nonpharmacologic management of musculoskeletal problems is preferred over pharmacologic (e.g., NSAID, Coxib, steroid, opioid) management because of the collateral benefits, safety, and cost-effectiveness associated with manual, dietary, botanical, and nutritional treatments. A brief discussion of the current crisis in musculoskeletal medicine is provided for contextualization and emphasis of the importance of expanding clinicians' knowledge of effective nondrug treatments...page 243

  4. Chapter 4. The Major Modifiable Factors in Sustained Inflammation: Major components of the “Functional Inflammology Protocol” are reviewed here, from concepts and molecular biology to an emphasis on practical clinical applications...page 303

   1) Food & Basic Nutrition...page 307
   2) Infections: Dysbiosis / Viral...page 396 / 540
   3) Nutritional Immunomodulation...page 609
   4) Dysmetabolism, Mitochondrial Dysfunction, ERS/UPR, mTOR...page 622
   5) Special Considerations: Sleep, Sociopsychology, Stress, Surgery...page 674
   6) Endocrine Imbalances...page 688
   7) Xenobiotic Immunotoxicity...page 699

5.  Chapter 5. Clinical Applications...page 713

   1) Hypertension...page 727
   2) Diabetes Mellitus...page 819
   3) Migraine & Headaches...page 863
   4) Fibromyalgia...page 901
   5) Allergic Inflammation...page 984
   6) Rheumatoid Arthritis...page 1019
   7) Psoriasis and Psoriatic Arthritis...page 1038
   8) Systemic Lupus Erythematosus...page 1053
   9) Scleroderma & Systemic Sclerosis...page 1074
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   11) Spondyloarthropathies & Reactive Arthritis...page 1108
   12) Sjögren Syndrome/Disease...page 1119
   13) Raynaud's Syndrome/Phenomenon/Disorder...page 1127
   14) Clinical Notes on Additional Conditions: Behçet's Disease, Sarcoidosis, Dermatomyositis and Polymyositis...page 1131
    

Index & Appendix -- page1154

 

 

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