Neuroinflammation in fibromyalgia and CRPS is multifactorial, not idiopathic
Citation: Vasquez A. Neuroinflammation in fibromyalgia and CRPS is multifactorial. Nature Reviews Rheumatology 2016; March 3: doi:10.1038/nrrheum.2016.25. http://www.nature.com/nrrheum/journal/vaop/ncurrent/full/nrrheum.2016.25.html
Basically what I do in this Correspondence is refute the idea that these "chronic pain" and neuroinflammatory / central sensitization conditions are "idiopathic" and are --rather and importantly-- multifactorial. The distinction is of massive importance, because if we view these conditions as multifactorial we can then begin to dismantle these conditions by addressing the components. Based on my previous work starting in 2004 on migraine (textbook: "Integrative Orthopedics") and 2008 on fibromyalgia (CME monograph: "Musculoskeletal Pain", now replaced by Inflammation Mastery, 4th Edition), I show --working within the constraints of less than 500 words-- that these conditions are triggered and perpetuated by 1) dysbiosis, 2) mitochondrial dysfunction, and 3) nutrient deficiencies, especially vitamin D. Logical treatment thereby follows, as already proven safe and effective by respective clinical trials.
My current textbooks (and previous journal articles) that cover this information are:
Inflammation Mastery, 4th Edition (2016); see hyperlinks: Please note the discount available viahttp://www.ichnfm.org/#!store---membership/wq28b Nondiscount/retail:http://amazon.com/author/alexvasquez
See also: Migraine and Headache Revolution
See also: Mitochondrial Medicine Arrives to Prime Time in Clinical Care. Altern Ther Health Med 2014
See also: Mitochondrial Dysfunction and the Emerging Mitochondrial Medicine. Integrative Medicine 2013
See also: Translating Microbiome (Microbiota) and Dysbiosis Research into Clinical Practice: The 20-Year Development of a Structured Approach that Gives Actionable Form to Intellectual Concepts. Int J Hum Nutr Funct Med 2015
See also: The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers. Altern Ther Health Med. 2004
